amyloid hypothesis造句

• The " amyloid hypothesis ", that the plaques are responsible for the pathology of Alzheimer's disease, is accepted by the majority of researchers but is by no means conclusively established.
• Collectively, the tafamidis and diflunisal data provide compelling pharmacologic evidence supporting the amyloid hypothesis, the idea that active transthyretin aggregation causes the loss of post-mitotic tissue in this degenerative amyloid disease.
• "We have placed our bet on the amyloid hypothesis, " is the way Dr . Eric Siemers of Eli Lilly & Co . puts it _ a statement that describes much of industry's focus.
• The traditional formulation of the amyloid hypothesis points to the cytotoxicity of mature aggregated amyloid fibrils, which are believed to be the toxic form of the protein responsible for disrupting the cell's calcium ion homeostasis and thus inducing apoptosis.
• They're betting on what is called the " amyloid hypothesis, " which holds that the basic flaw lies in the overproduction of A-beta ( specifically, a particularly pernicious type called A-beta 42, which clumps into insoluble filaments ).
• The amyloid hypothesis is initially compelling because the gene for the amyloid beta precursor APP is located on chromosome 21, and patients with trisomy 21-better known as Down syndrome-who thus have an extra gene copy almost universally exhibit AD-like disorders by 40 years of age.
• A more recent and broadly supported variation of the amyloid hypothesis identifies the cytotoxic species as an intermediate misfolded form of amyloid beta, neither a soluble monomer nor a mature aggregated polymer but an oligomeric species, possibly toroidal or star-shaped with a central channel that may induce apoptosis by physically piercing the cell membrane.